Part:BBa_K5477019
CYP1A1 - Cytochrome P450 1A1 from Rattus norvegicus
CYP1A1 (Cytochrome P450 1A1) is an enzyme in the cytochrome P450 family (CYPs). CYP1A1 plays a role in phase I metabolism by catalyzing oxygenation of the substrates, producing reactive intermediates that are often further processed by phase II enzymes (3). CYP1A1 metabolizes environmental toxins, including dioxins and polychlorinated biphenyls (PCBs) (1) (2).
CYP1A1 is integrated into a detoxification module where it initiates the oxidative breakdown of harmful pollutants. This part was combined with POR, that provides the reducing power to CYPs, in the composites. The following composites and devices, where this part was used, are listed below: BBa_K5477037 and BBa_K5477047
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 232
Illegal PstI site found at 1434 - 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 232
Illegal PstI site found at 1434 - 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 232
Illegal PstI site found at 1434 - 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 232
Illegal PstI site found at 1434
Illegal NgoMIV site found at 326
Illegal NgoMIV site found at 413 - 1000COMPATIBLE WITH RFC[1000]
References
1. Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, et al. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol. 2015 Mar;45(3):245–72.
2. Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T. Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. Int J Mol Sci. 2014 Aug 13;15(8):14044-57. doi: 10.3390/ijms150814044. PMID: 25123135; PMCID: PMC4159838.
3. Liu J, Tan Y, Song E, Song Y. A Critical Review of Polychlorinated Biphenyls Metabolism, Metabolites, and Their Correlation with Oxidative Stress. Chem Res Toxicol. 2020 Aug 17;33(8):2022–42.
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